Abstract
Poly(lactic-co-glycolic acid) (PLGA)/gelatin (Gt) ultrafine composite fibers were fabricated via electro-spinning. The effect of gelatin on the morphology and tensile property of the electrospun fiber mats was investigated. Mineralization was carried out in 10×simulated body fluid (10SBF). The deposited calcium phosphate (CaP) was identified by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). Results indicated that the average diameter of PLGA/Gt electrospun fibers was much smaller than that of PLGA fibers and the addition of gelatin increased the tenacity of wet mats. Two types of calcium phosphate deposits with different molar ratios of Ca/P were obtained when the electrospun PLGA/Gt mat was incubated in 10SBF. CaP crystals nucleated and grew faster on PLGA/Gt fiber mats rather than on PLGA membranes. “Honeycomb-like” crystals grew on the surface of PLGA/Gt electrospun fibers. After 4 h, the surface of the fibers was entirely coated with these crystals.
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