Abstract
Introduction: In order to increase primidone’s anticonvulsant action, the study set out to manufacture it in solid lipid nanoparticle form (PRI-SLN). Method: Microemulsification and ultrasonication procedures were used to create 17 PRI-SLN formulations. Results: The PRI-SLN displayed a high entrapment efficiency (46.37 ± 2.42% to 81.82 ± 1.21%), as well as small particle size (149.9 ± 6.72 to 188.8 ± 5.25 nm). According to the in-vitro release study, PRI from SLNs releases more slowly than PRI by itself. The thermal analysis showed the drug’s compatibility with other substances and its presence in the more soluble amorphous state. Following a lethal and chronic dosage of picrotoxin, the PRI-SLN exhibited a higher anticonvulsant efficacy, according to in-vivo research on rats (p< 0.05). Conclusion: SLN with stronger anticonvulsant action can be made from PRI.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
