Preliminary study of triclosan analysis: A GC/ECD optimization

Abstract

Abstract Triclosan is one of emerging contaminants with antimicrobial and disinfection properties. It is commonly used in soaps, toothpastes, detergents, hand sanitizers, disinfectants, and other personal care products. Triclosan is ubiquitous in environmental samples and its concentration in natural waters is drastically increase owing to the use of hand-sanitizer during COVID-19 pandemic. Triclosan cancer classification has not been determined yet, but recent studies and government assessments had shown its adverse effect, including as endocrine disruptor compound (EDC) to living things even at relatively low concentration. Triclosan analysis in environmental samples are mostly performed on LC/MS or GC/MS instruments. However, these instruments are relatively expensive. This study was aimed to optimize GC/ECD for triclosan quantification as an alternative to MS based instruments. Triclosan standard solutions at several concentrations were injected into the GC/ECD and the result is evaluated. The result showed that GC/ECD was able to detect triclosan at 0.1 ppb with good repeatability showed by %RSD of 0.48 %. The calibration curve at range of 0.1 to 1000 ppb showed a good linearity (r=0.99999).