Preliminary observation after off-pump coronary artery bypass systemic inflammatory response

Abstract

Objective The serum high-sensitivity C-reactive protein as a marker of inflammation,compared to the traditional off-pump coronary artery bypass evaluation of the off-pump coronary artery bypass grafting after systemic inflammatory response.Methods The selected 36 cages of coronary heart disease,the subgroup of off-pump coronary artery bypass grafting in 15 cases,off-pump coronary artery bypass grafting group of 21 patients,using latex assay were selected perioperative serum Hish-sensitivity C-reactive protein level,the two groups evaluate the operation of the whole body of the inflammatory response.Results The two groups of patients with serum high-sensitivity C-reactive protein level of pre-operative there was no significant difference(P＞0.05),off-pump coronary artery bypass graft surgery in the heparin group after 1 hours compared with the preoperative there was no significant difference(P＞0.05),12 hours after the increase(P＜0.05),24 hours peak(P＜0.01).Off-pump coronary artery bypass grafting off-pump group after 1 h and after the operation began earlier increased (P＜0.05),significantly increased after 12 h cardiopulmonary bypass(P＜0.05),24 h peak(P＜0.01).Serum high-sensitivity C-reactive protein level of the overall trend was similar,but the relatively low level of OPCAB group(P＜0.05).Conclusion Off-pump coronary artery bypass graft serum high-sensitivity C-reactive protein levels were significantly lower than off-pump coronary artery bypass grafting;off-pump coronary artery bypass grafting can effectively reduce the ischemia-reperfasion injury and the whole body Inflammatory response. Key words: Coronary artery bypass grafting; Cardiopulmonary bypass; Inflammation; C-reactive protein