Abstract
Pregnant mare's serum gonadotropin (PMSG) of 10 IU on day 5 of pregnancy induced luteal demise and consequently an absolute resorption of fetuses and placentae resulted on day 16 of pregnancy. Simultaneous regimen of PMSG and indomethacin or cortisone was found to be consistently effective in preventing the luteolytic effect of PMSG. The growth of the fetuses, placentae as well as corpora lutea was found to be parallel to controls. Similarly, shortening of the duration of pseucopregnancy to 10–12 days in the bilaterally hysterectomized rat by PMSG and its retaining the normal duration of 18–20 days in the presence of indomethacin tempt us to propose that the PMSG-incuced luteolysis is possibly reflected through the release of prostagland in at the ovarian level.
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