Abstract
PREFERENTIAL sensitization of hypoxic cells has great potential in the radiotherapy of human tumours, where radioresistant hypoxic tumour cells may limit the cures achieved by present methods of radiotherapy in some cases1. As an in vivo assay, the survival of epidermal cells after irradiation2 has been used to investigate the differential radiosensitizing properties of N-dimethylparanitro-2-propriophenone (NDPP) on hypoxic and well-oxygenated cells. NDPP has been selected on the basis of its electron affinity in a systematic search for a substance that can mimic oxygen in its radiosensitizing ability (refs. 3–5 and see accompanying report).
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