Abstract
Alzheimer's disease (AD) is a chronic, progressive brain disorder that slowly destroys affected individuals’ memory and reasoning faculties, and consequently, their ability to perform the simplest tasks. This study investigated the hub genes of AD. Proteins interact with other proteins and non-protein molecules, and these interactions play an important role in understanding protein function. Computational methods are useful for understanding biological problems, in particular, network analyses of protein-protein interactions. Through a protein network analysis, we identified the following top 10 hub genes associated with AD: PTGER3, C3AR1, NPY, ADCY2, CXCL12, CCR5, MTNR1A, CNR2, GRM2, and CXCL8. Through gene enrichment, it was identified that most gene functions could be classified as integral to the plasma membrane, G-protein coupled receptor activity, and cell communication under gene ontology, as well as involvement in signal transduction pathways. Based on the convergent functional genomics ranking, the prioritized genes were NPY, CXCL12, CCR5, and CNR2.
Highlights
As people become older, many parts of the body, including the brain, change
It is normal for people to become forgetful, and age-associated memory impairment is considered to be part of the aging process
It is understandable that people, especially the elderly, are concerned about memory loss, as it is a symptom of Alzheimer’s disease (AD)
Summary
It is normal for people to become forgetful, and age-associated memory impairment is considered to be part of the aging process. Alzheimer’s disease (AD) is distinct from age-associated memory impairment, and instead is a type of dementia that causes problems with memory, thinking, and behavior. It is well known that AD has complicated and diverse pathogenic causes, including genetic, environmental, and immunological factors, as well as head trauma, depression, and hypertension. AD typically occurs in elderly people (aged 65 years and above), while an uncommon variant known as early-onset AD comprises about 5% of AD cases [1]. People with early-onset AD develop symptoms during their 40s and 50s, the symptoms of both variants of AD are mostly the same
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