PP.37.21] RISK FACTORS OF SUBCLINICAL VASCULAR DAMAGE DETECTED BY DIFFERENT METHODS IN POPULATION-BASED SAMPLE OF SAINT-PETERSBURG INHABITANTS

Abstract

Objective: Different diagnostic procedures of subclinical vascular damage detection are now suggested but unequal impact of cardiovascular risk factors on arterial wall is still discussed. The aim of our study was to assess the association of cardiovascular risk factors with subclinical vascular changes according to different diagnostic methods. Design and method: 452 apparently healthy participants aged 25–65 years were randomly selected from 1600 Saint-Petersburg inhabitants (a sample form ESSE-RF study). All participants signed informed consent and filled in the questionnaire regarding risk factors, concomitant diseases and therapy. Fasting lipids, glucose (Abbott Architect 8000 (USA)), anthropometry and BP measurement (OMRON, Japan) were performed. Cardio-ankle vascular index (CAVI) was measured by VaSera VS-1500 (Fukuda, Japan), carotid-femoral pulse wave velocity (cfPWV) was measured by SphygmoCor (Atcor, Australia). Statistical analysis was performed using SPSS Statistics 20. Results: Most of patients 341 (75,4%) did not have subclinical vascular damage by both methods and only 3 patients (0,7%) had. Increased arterial stiffness detected by CAVI assessment (33 (7,3%)) was found out significantly more often (p < 0,005) in comparison with cfPWV assessment (21 (4,6%)). According to results of multiple logistic regression adjusted by sex and age, probability to reveal increased arterial stiffness by applanation tonometry (OR = 11,2, 95%CI = 3,6–34,9, p < 0,0001) was higher in comparison with volumetric sphygmography (OR = 3,3, 95%CI = 1,2–10,6, p = 0,03) in hypertensive patients. Association of arterial stiffness with age and hyperglycemia was found out only by cfPWV assessment: (OR = 1,13, 95%CI = 1,06–1,19, p < 0,0001) and (OR = 2,5, 95%CI = 1,1–6,2, p = 0,04) respectively. Conclusions: Hypertension and hyperglycemia are associated with increased arterial stiffness assessed by applanation tonometry. Applanation tonometry seems to give the opportunity to reveal increasing of arterial stiffness at earlier stages of hypertension in comparison with volumetric sphygmography.