ASSOCIATION OF SUBCLINICAL VASCULAR DAMAGE WITH DYSLIPIDEMIA IN ST. PETERSBURG POPULATION

Abstract

Objective: Subclinical vascular damage evaluation is believed to be useful for cardiovascular risk précising in non-high risk patients. Different diagnostic tools suggested for vascular structure and function assessment, while little is known about dyslipidemia impact into its damage development. The aim of the present study was to assess the association of dyslipidemia and different markers of subclinical vascular damage. Design and method: 1592 apparently healthy participants aged 25–65 years were randomly selected from Saint-Petersburg inhabitants (a sample from ESSE-RF epidemiology survey. All participants signed informed consent and filled in the questionnaire regarding risk factors, concomitant diseases and therapy. Fasting lipids, glucose (Abbott Architect 8000) and vital signs were obtained. 191 patients were excluded from the risk estimation due to the presence of cardiovascular complications. Cardio-ankle vascular index (CAVI), carotid-femoral pulse wave velocity (PWV-V) with amorphous probes and ankle-brachial index (ABI) were measured by VaSera VS-1500 (Fukuda). Measurement of intima-media thickness (IMT) was performed by My Sono U6 (Samsung). The subclinical vascular damage was detected, if PWV-V was >10m/s, CAVI >/= 9,0, ABI </= 0,9, IMT > 0,9 mm. Dyslipidemia was defined as cholesterol level > 4,9 mmol/l, or LDL cholesterol > 3,0 mmol/l, or medication prescribed for dyslipidemia. Statistical analysis was performed using SPSS Statistics 20. Results: Majority of participants (955 (76,7%)) had normal values of vascular damage markers.There was no correlation of PWV-V with lipid level, while IMT correlated with cholesterol and HDL level (β = 0,25, 95%CI [0,11–0,62], p = 0,04 and β=−0,15, 95%CI [−0,98-(-0,10)], p = 0,003 respectively). Conclusions: Dyslipidemia seems to be associated with carotid artery atherosclerosis, but not with arterial stiffness. Early detection of carotid atherosclerosis markers should be considered in patients with lipid disorders rather than measurement of arterial stiffness.