PP.19.31] ASSOCIATION OF SUBCLINICAL VASCULAR DAMAGE AND CARDIOVASCULAR RISK IN RUSSIAN POPULATION

Abstract

Objective: Subclinical vascular damage detection is one of valuable tool for precising of cardiovascular risk in non-high risk patients. Different diagnostic procedures of its detection are now suggested but unequal impact of cardiovascular risk factors on arterial wall is still discussed. The aim of our study was to assess the association of cardiovascular risk and subclinical vascular damage detected by different methods. Design and method: 1382 apparently healthy participants aged 25–65 years were randomly selected from Saint-Petersburg inhabitants (a sample form ESSE-RF study). All participants signed informed consent. Fasting lipids, glucose and BP measurement were performed. All patients were divided into low (< = 1%), intermediate (1–5%), high (5–10%) and very high (>10%) cardiovascular risk groups according to SCORE. 191 patients were excluded from the risk estimation due to presence of cardiovascular complications. Cardio-ankle vascular index (CAVI), carotid-femoral pulse wave velocity (cfPWV-V) and ankle brachial index (ABI) were measured by VaSera VS-1500, carotid-femoral pulse wave velocity (cfPWV-S) was detected by SphygmoCor only in 452 participants due to technical problems. Measurement of intima-media thickness (IMT) was performed by My Sono U6. The subclinical organ damage was detected, if cfPWV-V or cfPWV-S was >10m/s, CAVI > = 9,0, ABI < = 0,9, IMT>0,9 mm. Statistical analysis was performed using SPSS Statistics 20. Results: Most of patients 955 (76,7%) did not have subclinical vascular damage by any of methods. The subclinical vascular damage detected by IMT assessment was found out significantly more often (212 (24,7%)) in comparison with CAVI (75 (8,7%)) and ABI (18 (2,1%)) assessment, p < 0,005. Significant correlations of the SCORE logarithm with IMT (r = 0,61, p < 0,0001) and cfPWV-S (r = 0,38, p < 0,001) were revealed. Logical trend of growing CAVI in proportion to increase of SCORE risk level was observed, but it did not come up to significant level (r = 0,35, p = 0,14). ABI and cfPWV-V increasing were not associated with the growing level of cardiovascular risk. Conclusions: The number of subclinical vascular damage participants detected by IMT and cfPWV-S assessment increases in proportion to the growing level of cardiovascular risk according to SCORE. IMT and cfPWV-S might be considered as additional risk markers in cardiovascular risk stratification.