Abstract
A recent study (1) reported the effect of different methods of preparing triturations of either digoxin or hydrocortisone with lactose on the dissolution rates of these drugs. It was demonstrated that frictionally deposited drug, i.e., where the drugs were spread over the surface of the diluent by frictional pressure in a mortar and pestle, gave the highest dissolution rate. The other trituration methods investigated were simple blending by bottle tumbling, simple blending with ground drug, and solvent deposition.
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