Abstract
AbstractFour digoxin tablets have been formulated using potassium chloride and urea as water soluble directly compressible fillers. Simple blending and solvent deposition techniques were used for drug incorporation. The physical characteristics and content uniformity of the formulated tablets were comparable to those of two commercial brands of digoxin tablets. However, the dissolution rate of digoxin from tablets prepared by solvent deposition either on potassium chloride or urea (% dissolution after 1 h was 94 and 83 respectively) was higher than that from tablets made by simple blending (39 and 45% respectively)and superior to that of the two commercial brands (75.5% for both).
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