Formulation and Evaluation of Domperidone Medicated Jelly Using Solvent Deposition Method for Solubility Enhancement

Abstract

Abstract Objective: The purpose of this study is to develop and characterize medicated jelly of Domperidone. Domperidone is associated with poor aqueous solubility and dissolution rate and thus exhibit a poor bioavailability. Solvent deposition is a promising method to improve the solubility of poor water soluble drugs. Methods: Solvent depositions were prepared for optimization and evaluated for percentage drug content, invitro dissolution, solubility analysis. Optimization of Domperidone solvent deposition was done using 3 2 Factorial design.Optimized formulation was incorporated into jellies and were examined. Results: In-vitro dissolution studies showed that solvent deposition enhances the dissolution properties of pure Domperidone. The in vitro drug release study of medicated jelly indicates that it enhances the dissolution property of Domperidone. Stability studies of prepared medicated jellies confirm that it remain stable throughout the period of study. Conclusion: The solvent deposition prepared in this work is known to improve solubility and dissolution characteristics of a poor water soluble drug Domperidone. The prepared medicated jellies can be a promising dosage form for delivery of drugs. Keywords: Solvent deposition, domperidone maleate, jelly, optimization , solubility enhancement Cite this Article Arun Raj. R, JibcyFeba Rachel John, Jyoti Harindran. Formulation and Evaluation of Domperidone Medicated Jelly Using Solvent Deposition Method for Solubility Enhancement. Research & Reviews: A Journal of Drug Formulation, Development and Production . 2017; 4(2): 40–53p.