Abstract
ABSTRACT Lung cancer is the most prevalent and main cause of tumour-related deaths across the world. Exposure to environmental and occupational toxicants such as toxic trace elements is an important cause of lung carcinoma. Keeping in view, the current investigation was aimed to measure the concentrations of 10 elements Mn, Mg, Ni, Zn, Se, Cr, Cd, Fe, Pb and Cu in the malignant tissues and non-malignant tissues samples of lungs of patients. The samples were digested in HNO3 and HClO4 solutions and analysed by using atomic absorption spectrophotometric technique. On the average, significantly elevated levels of copper , lead , cadmium and chromium were detected in the malignant tissues than the non-malignant tissues of patients. Most of the elements exhibited noticeably disparities in their concentrations based on sex, nutritional habits, habitat and smoking habits of donor groups. The correlation coefficients between the elements in malignant tissues and non-malignant tissues were significantly diversed. Based on lung cancer types, zinc and cadmium were raised in adenocarcinoma, whereas copper and cadmium were elevated in squamous cell carcinoma patients. Average magnesium, zinc and lead were highest in stage IV, while nickel and iron were maximum in stage-III of the malignant tissues. The chromium and manganese referred to be maximum at stage-II while selenium, copper and cadmium were elevated at stage-I. Multivariate statistical methods based on the elemental concentrations exhibited clearly divergent groupings which may be linked to alter the metabolism of the metals in the tumour tissues and non tumour tissues of lungs.
Published Version
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