Abstract
Albumin microspheres were prepared by two different stabilization processes: chemical denaturation and heat denaturation. The extent of stabilization was characterized by the solubility and the swelling properties of the microspheres. In vitro drug (prednisolone) release rates were determined for the different microsphere preparations and the results were correlated to the stability of the microspheres. Heat denaturation had a significant effect on the in vitro release rates; the more denatured the albumin, the slower the drug release rate. Chemical denaturation, using glutaraldehyde, did not have a marked effect on drug release from the microspheres. Two of the major limitations of albumin microsphere systems i.e. poor drug entrapment and premature release (“burst effect”) have been overcome using prednisolone loaded heat denatured microspheres.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
