Abstract
Corona virus or Covid-19 infection that has rapidly evolved into a global pandemic shortly after its emergence in China in December 2019, demands smart, preventive and treatment recommendations especially related to its early onset symptoms. Anosmia, has now been identified among one of the earliest presenting symptoms in Covid-19 patients. Reports of anosmia in otherwise asymptomatic persons have led to interest in this sign as a potential early indicator of this disease Medical publications about anosmia with COVID-19 are still uncertain of its causative mechanism.
 The aim of this review is to provide literature review, as well as evidence-based recommendations for the management of patients with COVID-19 related anosmia, using Chamomile (Matrricaria chamomilla) extract nasal irrigation.
 Extensive database search from PubMed, Cochrane library, and Web of science, gray literature searches from Google Scholar, WHO and Traditional Persian Medicine textbook search such as Makhzan al Adwiyehe was performed.
 To support the literature, 8 most recent articles published in current year including systematic reviews and meta-analysis as well as clinical trial studies were finally selected to see the effectiveness of Chamomile in treatment of various symptoms of Covid-19.
 Chamomile (Matrricaria chamomilla) extract based on its pigenin and Luteolin (causing reduction of leukocyte infiltration), a-Bisabolol (which has anti-inflammatory role), Chamazulene (that provides anti-inflammatory and antipyretic role), Guaiazulene (antipyretic), Matricin (Anti-inflammatory role) and other appreciated roles mentioned in this study may serve as a promising treatment for Covid-19 induced anosmia, especially when used as nasal irrigation. 
 Keywords: Chamomile, Covid-19 related Anosmia, Babouneh, loss of smell.
Highlights
Anosmia or loss of smell is broadly defined as olfactory dysfunction(OD)
After the emergence of spectrum of Covid-19 symptoms, an association between Covid-19 and olfactory and gustatory dysfunctions (OGDs) was established (Akosua Adom Agyeman, 2020)i so much so that high prevalence of OGDs among patients infected with COVID-19 was observed worldwide
Recent studies in 2020 showing Chamomile effectiveness in Covid-19 related symptoms: Systematic reviews and meta-analysis as well as clinical trial studies, that were published in last 5 years were studied to see the effectiveness of Chamomile on anosmia, nasal inflammation and allergic symptoms
Summary
Anosmia or loss of smell is broadly defined as olfactory dysfunction(OD). In the United Kingdom, a surge in patients seeking medical advice just related to the onset of self-diagnosed loss of sense of smell was reported (Akosua ,2020)ii. In Germany, almost 2 in 3 confirmed reported loss of smell and taste, along with either active or incubatory period of Covid-19. A significant increase in the number of patients presenting with anosmia who otherwise have mild symptoms or in the absence of other symptoms, according to many anecdotal evidences have been reported. In a study of 3191 COVID-19+ patients who were self-isolating at home with mild disease, 15.3% expressed smell or taste loss (Hopkins, 2020)iv
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
