Abstract
Objective: The aim of the study was to validate the traditional fertility regulating claims by investigating the effect of root bark extract of both plants on ovarian and uterine structures.Materials and Methods: Twenty five mature normocyclic female winstar rats were used. Group 1 consisted of 5 animals that acted as control. Group 2 and 3 with 5 animals each; received 500 and 800mg/ Kg Croton menyharthii respectively on alternative days for 28 days through intra- abdominal gavage. Group 4 and 5 were treated in a similar manner but received Uvariodendron kirkii aqueous extract. Left ovaries and uterus were harvested and processed for histomorphology.Results: Croton menyharthii and Uvariodendron kirkii extracts caused a reduction in primordial and antral follicles, disrupted granulosa and theca cells with significant degeneration of ova. Â Croton menyharthii caused a disruption of uterine endothelial structure and loss of villi. Uvariodendron kirkii aqueous extract caused a significant uterine gland vacuolation and a thickened endothelial lining with an intact endothelial cell layer and its invaginations. Disrupted ovarian and uterine structure possibly led to compromised fertility and implantation.Conclusion: The study validates the traditional use of the plant in fertility regulation. We suggest further investigation on these potential plants to address the call for novel contraceptive drugs.Â
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