Abstract
Background: Forskolin, an active compound extracted from the Coleus forskohlii plant, has a wide range of potential functions including losses of body weight, improves diabetes and improves cardiovascular health. Methods: Thirty sex albino mice, growing and adult males and females were classified into two groups; control group (G1) fed basal control diet versus C. forskolin group fed basal control diet containing C. forskolin leaves (G2; 1.5%) for four weeks. Changes of body and liver weight were recorded. Rectal temperature and glucose values were determined. In addition, blood samples were collected and were subjected for serum biochemistry analysis. Result: The results indicated that C. forskolin caused significant decrease (P less than 0.05) in body weight and glucose values in addition to significant increase (P less than 0.05) in rectal temperature. In addition, serum biochemistry parameters (total protein, blood urea nitrogen, creatinine, aspartate aminotransferase and alanine transferases, lactate dehydrogenase) were changed due to C. forskolin compared to control diet. It could be concluded that 1.5% C. forskolin supplementation modulates thermo-tolerance responses, blood glucose indices and serum metabolites.
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