Abstract
Assessment of cytotoxicity, antibacterial activity and phytochemical screening of ethanol extract of Phyllanthus acidus L. (family: Euphorbiacceae) BarkSubrata Kumar Biswas, Anusua Chowdhury, Joysree Das, Utpal Kumar Karmakar, Manik Chandra Shill, Sheikh Zahir Raihan
Highlights
Cancer is a disease caused by decreased apoptosis activity and dysregulation of abnormal cell proliferation that attacks and disturbs surrounding tissue, and the spread is not controlled, resulting in death (Mas’ula and Kusuma, 2015)
This study aimed to identify secondary metabolites of P. canescens leaf chloroform fraction and subfraction and to determine the effect of cytotoxicity (IC50) on HT-29 colon cancer cells
The tests carried out showed that chloroform subfraction 3 showed potential cytotoxic activity in human HT-29 cancer cells with an IC50 value of 14.807 μg/ml and provided promising hope for further cytotoxicity studies
Summary
Cancer is a disease caused by decreased apoptosis activity and dysregulation of abnormal cell proliferation that attacks and disturbs surrounding tissue, and the spread is not controlled, resulting in death (Mas’ula and Kusuma, 2015). The first mutation caused by cell division results in a homogeneous genetic clone; further mutations occur, which cause an increased potential cell growth (American Cancer Society, 2017). Colorectal cancer is caused by abnormal cells in the colon or rectum and often begins as a growth called polyps in the colon or rectum. The secondary metabolites (such as alkaloids, terpenoids, flavonoids, phenolics, and organic acids) found in various plants have been shown to inhibit cancer cells’ growth (Fadilah et al, 2017; Gautam, 2015). In most living organisms formed among other alkaloids, terpenoids and flavonoids have potential anticancer activities (Saifudin, 2014; Yang and Dou, 2010)
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