Abstract
Polyunsaturated Fatty Acids Play a Role in Depression: Main Action Mechanisms
Highlights
The omega-3 and omega-6 Polyunsaturated Fatty Acids (PUFAs) are either synthesized from the essential fatty ACIDs α-Linolenic Acid (ALA) and Linoleic Acid (LA) respectively, or obtained from the diet
Clinical and epidemiological data favour the hypothesis that PUFAs could play a role in pathogenesis and treatment of depression [1,2]
Preliminary data from depressed patients suggest that inhibiting proinflammatory cytokines or their signaling pathways may improve depressed mood and increase treatment response to conventional antidepressant medication [4]
Summary
The omega-3 and omega-6 Polyunsaturated Fatty Acids (PUFAs) are either synthesized from the essential fatty ACIDs α-Linolenic Acid (ALA) and Linoleic Acid (LA) respectively, or obtained from the diet. Omega-3 PUFAs, Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) are found predominantly in oily fish such as salmon, mackerel and sardines. Clinical and epidemiological data favour the hypothesis that PUFAs could play a role in pathogenesis and treatment of depression [1,2]. The aim of this work is to summarize the main mechanisms whereby PUFAs may exert this role.
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