Abstract
Introduction:Anti-angiogenic therapy can produce transient regression in tumor in case of Glioblastoma (GBM); however, no prolongation of patient survival rate had so far been achieved.Methodology:To address this problem, an effort was made to design and characterize a temozolomide loaded nanosystem for targeting the tumor vasculature in the brain using polymeric nanoparticles. It included the formation of Temozolomide (TMZ) loaded Solid-Lipid Nanoparticles (SLNs) and their conjugation with polysorbate-80 (P-80) which enhanced the penetration of drug to blood-brain barrier resulting in the enhancement of pro-apoptotic activity.Results:Conjugating nanoparticles with a tumor-penetrating polymer (P-80) further enhanced the therapeutic efficacy of the drug.Conclusion:The animal studies indicated the enhanced potential of the developed system in the effective treatment of glioblastoma.
Highlights
Anti-angiogenic therapy can produce transient regression in tumor in case of Glioblastoma (GBM); no prolongation of patient survival rate had so far been achieved
The animal studies indicated the enhanced potential of the developed system in the effective treatment of glioblastoma
Many novel drug delivery systems have been designed to improve the bioavailability of drug to brains including nanoparticles, micellar systems, microemulsion, solid lipid nanoparticles, liposomes, niosomes etc. [9 - 12]
Summary
Anti-angiogenic therapy can produce transient regression in tumor in case of Glioblastoma (GBM); no prolongation of patient survival rate had so far been achieved. Various treatment strategies including surgery, chemotherapy have been available to control the progression of diseases, but still mortality rate against brain cancer is very high [1, 2]. This may be attributed to the development of resistance against existing treatment strategies [3]. Nanoparticles based delivery of drugs to the brain has shown significant potential Nanometric size of these particulate carriers improves the permeation and availability of drugs to the brain, and provides a large surface area, improves solubility and ability to encapsulate both hydrophilic and lipophilic drugs.
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