Abstract
AbstractInfection and chronic inflammation caused by oxidative stress are the main challenges in chronic wound healing. In this study, a silk fibroin/kappa‐carrageenan (kCA)‐based hydrogel functionalized with epigallocatechin‐3‐gallate (EGCG) and Cu2+ is fabricated for chronic wound healing. Polyphenol–metal functional complexes and ionic‐covalent entanglement networks are prepared by introducing Cu2+. Cu2+ coordinates with kCA to enhance the mechanical properties and chelates with EGCG to form an EGCG‐Cu2+ complex that continuously releases EGCG. The sustained release of EGCG enhances the antibacterial properties by synergizing with the effects of Cu2+. Furthermore, the prepared hydrogel exhibits a potent ability to scavenge excessive intracellular reactive oxygen species, controllable antioxidant bioactivity, and reliable biocompatibility. Ultimately, the resulting multifunctional hydrogel dressing provides a potential and effective strategy for chronic wound care management with increased mechanical strength and antibacterial and antioxidant properties.
Published Version
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