Abstract
SNP (single-nucleotide polymorphism) of rs10903129 near the TMEM (transmembrane protein) 57 locus has been associated with TC (total cholesterol) in a previous GWAS (genome-wide association study), but the association of TMEM57 rs873308 SNP and serum lipid levels has not been previously reported. The current study was undertaken to detect the association of the TMEM57 rs873308 SNP and several environmental factors with serum lipid profiles in the Han Chinese and Mulao populations. The genotypes of the TMEM57 rs873308 SNP in 865 individuals of Han Chinese and 902 participants of Mulao nationality were determined by PCR and RFLP (restriction-fragment-length polymorphism) combined with gel electrophoresis and then confirmed by direct sequencing. The T allele frequency of TMEM57 rs873308 SNP was not different between Han and Mulao (23.18% versus 25.72%, P>0.05), but different between males and females in the two ethnic groups (P<0.05). The T allele carriers had lower serum TC, Apo (apolipoprotein) B, HDL-C (high-density lipoprotein cholesterol) levels, ApoA1/ApoB ratio in Han; and lower TAG (triacylglycerol), LDL-C (low-density lipoprotein cholesterol), ApoA1 levels and the ApoA1/ApoB ratio and higher HDL-C levels in Mulao than the T allele non-carriers. There was also different association of the TMEM57 rs873308 SNP and serum lipid profiles between males and females in the both ethnic groups. Serum lipid parameters in the two ethnic groups were also associated with several environmental factors. The association of the TMEM57 rs873308 SNP and serum lipid levels was different in the Han Chinese and Mulao populations and between males and females in the both ethnic groups. There may be a sex-specific association of the TMEM57 rs873308 SNP and serum lipid levels in our study populations.
Highlights
coronary heart disease (CHD) is one of the world’s top ‘economic killer’ as well as its likely leading cause of death in the world [1]
Serum TAG, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL)-C, ApoA1 levels and the ApoA1/ApoB ratio were different among the genotypes in Mulao (P < 0.05–0.001), the T allele carriers had lower serum TAG, low-density lipoprotein cholesterol (LDL-C), ApoA1 levels and the ApoA1/ApoB ratio and higher serum HDL-C levels than the T allele noncarriers
Subgroup analyses showed that serum total cholesterol (TC), TAG, HDLC, ApoB levels and the ApoA1/ApoB ratio in Han males and serum TAG, HDL-C, ApoA1 levels and the ApoA1/ApoB ratio in Han females were different among the genotypes (P < 0.05– 0.001); the T allele carriers had lower serum TC, TAG and ApoB levels and higher serum HDL-C level and the ApoA1/ApoB ratio than the T allele non-carriers in Han males (P < 0.05–0.001)
Summary
CHD (coronary heart disease) is one of the world’s top ‘economic killer’ as well as its likely leading cause of death in the world [1]. The estimated direct cost of CHD in 2010 was $272.5 billion, and it is projected to reach $818 billion by 2030 in America [2]. It is a universally acknowledged truth that dyslipidaemia is presumed to play a vital role in someone susceptible to CHD [3]. Serum or plasma TC (total cholesterol) [4], TAG (triacylglycerol) [5], HDL-C (high-density lipoprotein cholesterol) [6], LDL-C (low-density lipoprotein cholesterol) [7], Apo (apolipoprotein) A1 [8], ApoB [9] and ApoA1/ApoB ratio [10] were traditionally monitored as predictors of CHD events and the main target for therapeutic intervention.
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