Abstract
In previous studies on the secondary metabolites of the Taiwanese octocoral Isis hippuris, specimens have always been collected at Green Island. In the course of our studies on bioactive compounds from marine organisms, the acetone-solubles of the Taiwanese octocoral I. hippuris collected at Orchid Island have led to the isolation of five new polyoxygenated steroids: hipposterone M–O (1–3), hipposterol G (4) and hippuristeroketal A (5). The structures of these compounds were determined on the basis of their spectroscopic and physical data. The anti-HCMV (human cytomegalovirus) activity of 1–5 and their cytotoxicity against selected cell lines were evaluated. Compound 2 exhibited inhibitory activity against HCMV, with an EC50 value of 6.0 μg/mL.
Highlights
I. hippuris were all collected at Green Island [5,6,7,12,14,15]
High-performance liquid chromatography (HPLC) was carried out using a Hitachi L-7100 pump equipped with a Hitachi L-7400 UV detector at 220 nm together with a semi-preparative reversed-phase column (Merck, Hibar LiChrospher RP-18e, 5 μm, 250 × 25 mm)
The octocoral I. hippuris was collected by hand using scuba at Orchid Island, 70 km off the southeastern coast of Taiwan, in August 2008 at a depth of 9 m and stored in a freezer until extraction
Summary
The octocoral Isis hippuris, distributed widely in the western Pacific, has yielded a number of polyoxygenated steroids, including hippuristanol type [1,2,3,4,5,6,7,8,9], gorgosterol type [10,11,12,13,14], hippuristerone type [3,14,15], and hippuristerol type [3,14,15,16] Those of the first type were originally reported as cytotoxins and later rediscovered as selective inhibitors against the translation factor eIF4A [17,18]. We describe the isolation, structure elucidation, and biological activity of these compounds
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