Abstract
In the continued search for novel bioactive substances from the Taiwanese octocoral Briareum excavatum collected at Orchid Island, three new briarane-type diterpenoids, briacavatolides D–F (1–3) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1–3 and their cytotoxicity against selected cancer cell lines were evaluated.
Highlights
Briarane-type diterpenoids, a group of diterpenoids having a highly oxidized bicyclo[8.4.0] system with a γ-lactone group are found only in marine organisms and mainly from octocorals [1,2,3,4]
The sliced bodies of the Taiwanese octocoral B. excavatum were exhaustively extracted with acetone
Cytotoxicity was determined on P-388, HT-29, and A-549 tumor cells using a modification of the MTT colorimetric method according to a previously described procedure [8,9,10]
Summary
Briarane-type diterpenoids, a group of diterpenoids having a highly oxidized bicyclo[8.4.0] system with a γ-lactone group are found only in marine organisms and mainly from octocorals [1,2,3,4]. The compounds of this type are proven to possess various bioactivities such as anti-inflammatory, cytotoxicity, and antibacterial activity [1,2,3,4]. Human cytomegalovirus (HCMV) is a highly ubiquitous pathogen with a global prevalence of. The anti-HCMV (human cytomegalovirus) activity of 1–3 and their cytotoxicity against selected cell lines were evaluated
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