Abstract
In order to search for novel bioactive substances from marine organisms, we have investigated the organic extracts of the Taiwanese octocoral Briareum excavatum collected at Orchid Island. Three new briarane-type diterpenoids, briacavatolides A–C (1–3) as well as two known briaranes, briaexcavatolide U (4) and briaexcavatin L (5) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1–5 and their cytotoxicity against selected cancer cell lines were evaluated.
Highlights
Briarane-type diterpenoids, a group of diterpenoids having a highly oxidized bicyclo[8.4.0] system with a γ-lactone group are found only in marine organisms and mainly from octocorals [1,2,3]
The octocoral B. excavatum was collected by hand using scuba at Orchid Island off Taiwan, in July
Cytotoxicity was determined on P-388, HT-29, and A-549 tumor cells using a modification of the MTT colorimetric method according to a previously described procedure [6,7]
Summary
Briarane-type diterpenoids, a group of diterpenoids having a highly oxidized bicyclo[8.4.0] system with a γ-lactone group are found only in marine organisms and mainly from octocorals [1,2,3]. The compounds of this type are proven to possess various bioactivities such as anti-inflammatory, cytotoxicity, Mar. Drugs 2012, 10 and antibacterial activity [1,2,3]. The first chemical investigation of B. excavatum (Figure 1) collected at Orchid Island off Taiwan during August 2008 afforded three new briarane-type diterpenoids, briacavatolides A–C (1–3). The anti-HCMV (human cytomegalovirus) activity of 1–5 and their cytotoxicity against selected cell lines were evaluated
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
