Abstract
1. 1. Initiation, but not elongation of RNA synthesis by Qβ replicase is completely inhibited by polyethylene sulfonate at low concentrations. 2. 2. Polyethylene sulfonate affects a step subsequent to the primary binding of Qβ RNA to replicase and prior to the formation of the first few internucleotide bonds. 3. 3. Addition of polyethylene sulfonate to a Qβ RNA-directed Qβ replicase reaction, after initiation has taken place, leads to the exclusive formation of free, single-stranded minus strands. 4. 4. The inhibition by polyethylene sulfonate can be reversed by the addition of an appropriate quantity of protamine sulfate.
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