Abstract
Over the past several years, great advances have been made towards novel drug delivery systems. The phenomena of interpolymer interactions and formation of polyelectrolyte complexes have been the focus of intensive fundamental and applied research. Interpolyelectrolyte complexes combine unique physicochemical properties with high biocompatibility. Studies have been carried out on many different polymer blends and types. Such combinations may possess unique properties that are different from those of individual component. The present review emphasizes on the applicability of polyelectrolyte complexes in drug delivery technology.
Highlights
Over the past several years, great advances have been made towards novel drug delivery systems
These techniques are capable of controlling the rate of drug delivery, sustaining the duration of therapeutic activity and/ or targeting the drug to specific tissues
These advancements led to the development of several novel drug delivery systems, revolutionizing the medication with several advantages
Summary
Polyelectrolyte Complexes: A Review of their Applicability in Drug Delivery Technology. The driving force behind these transitions include stimuli like neutralization of charged groups by either a pH shift or the addition of an oppositely charged polymer, changes in the efÞciency of hydrogen bonding with an increase in temperature or ionic strength and collapse of hydrogels and interpenetration of polymer network These types of polymers convert the active substances into a non-deleterious form which can be administered, and have speciÞc effect on the biodistribution, bioavailability or absorption of the active substances and increasingly gaining importance in modern pharmaceutical technology. The polyelectrolyte complexes formed between a poly acid and poly base are little affected by the pH variation of the dissolution medium This concept of complexation, between DNA and chitosan[2], has extensively been studied in the development of delivery vehicle for gene therapy and oral vaccination. There have been theories proposed based on the electrostatic forces and Flory-Huggins mixing
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