Abstract
Using tetracycline-HCl and theophylline as model drugs, polyacrylamide microbeads were prepared by w/o emulsion polymerization technique. Furthermore, drug-loaded polymer microbeads were prepared in the presence of different concentrations of gelatin, which were further cross-linked for different time intervals. The prepared microbeads were characterized through particle size analysis, electron microscopy, and in vitro dissolution. Relatively spherical free-flowing populations of microbeads were obtained. The presence of gelatin during the polymerization processes led to larger particles proportional to its concentration in the aqueous phase. The dried microbeads showed smooth pored or fissured surfaces. In aqueous media, they attained equilibrium hydration within 10 min, with 73.5% v/v water uptake forming spongy spheres. The products showed slower dissolution rates with higher gelatin concentrations and extended cross-linking.
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