Abstract
Poly(butylene succinate) (PBSU) is a biodegradable and biocompatible synthetic aliphatic polyester, which has been used extensively in packaging, catering and agriculture, and more recently in drug delivery and bone and cartilage repair. PBSU-based mats created by electrospinning show promise as wound dressing materials because of their good mechanical properties, high surface area-to-volume ratio and increased levels of porosity. In this work, we present the creation of antimicrobial PBSU fibrous mats through the incorporation of natural food grade agents via blend electrospinning. Three types of edible gums (namely arabic, karaya and tragacanth), two essential oils (coriander and lavender), and one free fatty acid (linoleic acid) were added to PBSU containing a chain extender and their effect on six clinically relevant pathogens was evaluated. Mats containing essential oils at the highest concentration studied (7% w/v) showed some antimicrobial behaviour against S. aureus, E. hirae and P. aeruginosa, whereas the incorporation of linoleic acid at both concentrations tested (3% and 5% w/v) gave a strong reaction against S. pyogenes. Gum arabic was the only gum that had a considerable impact on S. aureus. Furthermore, the three gums enhanced the mechanical properties of the polymer mats and brought them closer to those of the human skin, whilst all agents maintained the high biocompatibility of the PBSU mats when contacted with mouse fibroblasts. This work, for the first time, shows the great promise of PBSU blended fibres as a skin substitute and paves the way towards bioactive and cost effective wound dressings from renewable materials.
Highlights
Poly(butylene succinate) (PBSU) is a synthetic aliphatic polyester, which can be produced from biomass-based raw materials, as well as the traditional petrochemical route
PBSU copolymer-based nanoparticles have been used as drug delivery vehicles, whereas various scaffold configurations have been employed for bone and cartilage repair [13,14], as well as in wound healing [15]
Additional investigation into the effect of flow rate, voltage and tip to collector distance on the fibre diameter showed that increasing the flowrate and/or reducing the to collector distances (TCD) has a negative impact on fibre homogeneity (Figure 1) [36,37]
Summary
Poly(butylene succinate) (PBSU) is a synthetic aliphatic polyester, which can be produced from biomass-based raw materials, as well as the traditional petrochemical route. Since its commercial introduction in 1993, PBSU has gained popularity in various areas, including packaging, catering and agriculture [1,2,3]. PBSU has found application in the biomedical field, in tissue engineering and drug delivery [4,5,6]. PBSU copolymer-based nanoparticles have been used as drug delivery vehicles, whereas various scaffold configurations have been employed for bone and cartilage repair [13,14], as well as in wound healing [15].
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