Abstract
Poly 8-bromoguanylic acid (poly BrG) and several copolymers with guanylic acid were prepared by direct bromination of poly G. The homopolymer possesses several unusual spectral properties. In the optical rotatory dispersion spectrum, the Cotton effect at long wavelengths is inverted relative to those shown by poly G, poly N 1-methyl G and poly N 7-methyl G. Similarly, the circular dichroic spectrum was qualitatively different from those of available reference polymers. Unlike poly G, poly BrG fails to form complexes with either poly C or poly dC. These results, in conjunction with examination of models of 8-substituted purine nucleotide monomers and polymers are consistent with the concept that the nucleotide residues in poly BrG do not assume the normal anti conformation. Physical characteristics of ApBrG and BrGpA compared with their corresponding normal dinucleoside phosphates ApG and GpA are also described.
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