Abstract
Microparticles with strong adhesion property was presented as efficacious drug delivery systems. Here, inspired by natural pollen, polymer microparticles with surface textures and homogeneous size were fabricated through evaporation-induced interfacial instability of microfluidic droplets templates. The resultant particles exhibited controllable surface roughness and thus strong adhesion ability to the intestinal mucosa. Such particles were employed as novel drug carriers, which contributed to enhanced loading efficacy and controllable release kinetics, and were proved to increase therapeutic effectiveness through in vivo and in vitro tests, thus playing a potential role in sustained drug delivery, bioimaging, diagnostics, etc.
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