Bioprinting of hepatic tissue using 3D technology: Transitioning beyond laboratory models to real-world applications in medical treatments

Abstract

This study discusses the potential for mending portions or entire hepatic to cure persistent liver disease. Fabricating functioning organs is the ultimate objective of tissue science, and this study highlights the possibility of being accomplished. The liver, the most significant gland in the human body, serves as accountable for a wide range of metabolism-related processes and activities. Persistent liver failure is a prevalent cause of mortality worldwide, and the currently prevalent technique of organ transplantation has challenges. Therefore, it is necessary to develop an artificial liver model in the laboratory that accurately replicates the natural surroundings. The generated model should be dependable in comprehending the etiology, evaluating medications, and aiding in the restoration and substitution of the impaired liver. 3-D bioprinting is a promising method that develops an in vitro model that closely resembles the in vivo environment, with the ultimate aim of being used for transplantation by tissue engineers. The technique has significant promise as a result of its exact manipulation and its capacity to uniformly disperse cells across all levels inside an intricate framework. This study provides a comprehensive examination of liver tissue engineering, specifically highlighting the use of three-dimensional bioprinting and bio-inks for liver disease models and pharmaceutical screening.