Abstract
Podocyte Injury in Diabetic Nephropathy
Highlights
Diabetic nephropathy (DN) is one of the most common chronic serious complications of diabetes mellitus (DM) and the leading cause of end-stage renal disease
We summarize the present recognitions on the pathogenesis of DN, and highlight the relationship between podocyte injury and DN, which may help us to prevent and treat DN
Research showed that prorenin binds to prorenin receptor (PRR) to transform into renin with catalytic activity by means of change of molecular conformation and exposure to active site, Ang II generates and participates in the pathogenesis of DN (Ang II dependent pathway)
Summary
Received: December 8, 2016 Revised: January 22, 2017 Accepted: January 24, 2017 Published online: March 24, 2017
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
