Abstract
Aim : To evaluate the role of family history of enuresis, associated comorbidities and body mass index in predicting response to enuresis treatment with desmopressin in children. Materials amd methods : 100 patients with monosymptomatic enuresis were evaluated in this retrospective study. The associations between family history of enuresis, associated comorbidities, body mass index and response to enuresis treatment with desmopressin were analysed with χ 2 statistical test. Results : Family history of enuresis was positive in 58.8 % of patients who responded to desmopressin treatment and in 54.5 % of non-responders. Among patients who responded to desmopressin treatment, obesity was present in 14.3 % and overweight in 19 % of patients. Among non-responders, obesity was present in 13.2 % and overweight in 7.9 % of patients. Among patients who responded to desmopressin treatment, comorbidity was present in 40.5 % of patients. Among 38 non-responders, comorbidity was present in 21.1 % of patients. The difference was not statistically significant in either of compared groups. Conclusion : The study did not prove statistically significant association between family history of enuresis, associated comorbidities or body mass index, and response to treatment with desmopressin.
Highlights
Enuresis is common in school age children
The associations between family history of enuresis, associated comorbidities, body mass index and response to enuresis treatment with desmopressin were analysed with χ2 statistical test
The occurrence of primary nocturnal enuresis was found to be 8.7% in the population of Slovenian 5-year olds which is comparable with data from other countries[1]
Summary
Enuresis is common in school age children. The occurrence of primary nocturnal enuresis was found to be 8.7% in the population of Slovenian 5-year olds which is comparable with data from other countries[1]. Desmopressin is a vasopressin analogue and is the most widely used drug for treatment of monosymptomatic nocturnal enuresis with proven efficacy. It is considered as the first-line treatment, especially for children with enuresis in families who are not motivated enough to use the alarm therapy, who have recently unsuccessfully used the alarm or in those who are unlikely to use it correctly[2]. Several factors have been proposed to negatively influence clinical response to desmopressin treatment. Response to treatment of enuresis compared with tablet, in children with primary monosymptomatic nocturnal enuresis, mainly due to increased compliance[5,6]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call