Abstract
AbstractActivation and degranulation of platelets releases cytokines that have effects on soft tissue and bone healing. Delivery of these growth factors to the site of wound healing may be achieved by preparation of a gel from platelet‐rich plasma, with or without the inclusion of the leukocyte fraction. This review describes the individual actions of the cytokines present in this gel, their effects on wound and bone healing, and the different methods of preparation of growth‐factor‐rich gels. Clinical results in the fields of bone and soft tissue healing, especially in the areas of maxillofacial and spinal surgery, are summarized.
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