Abstract
Chronic nonhealing wounds pose a serious challenge to regaining skin function and integrity. Platelet-derived extracellular vesicles (PEVs) are nanostructured particles with the potential to promote wound healing since they can enhance neovascularization and cell migration and reduce inflammation and scarring. This work provides an innovative overview of the technical laboratory issues in PEV production, PEVs' role in chronic wound healingand the benefits and challenges in its clinical translation. The article also explores the challenges of proper sourcing, extraction techniquesand storage conditions, anddiscusses the necessity of further evaluations and combinational therapeutics, including dressing biomaterials, M2-derived exosomes, mesenchymal stem cells-derived extracellular vesiclesand microneedle technology, to boost their therapeutic efficacy as advanced strategies for wound healing.
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