Abstract
El Granuloma de Celulas Plasmaticas es una rara lesion tumoral benigna descrita dentro de la clasificacion de tumores pseudoinflamatorios, es rara su aparicion dentro de la cavidad oral, haciendo realmente complicado su diagnostico y tratamiento, ya que presenta similitud clinica con patologias tumorales malignas. Para el adecuado diagnostico y tratamiento del GCP, se requiere de la realizacion de biopsia y estudio histopatologico/inmunohistoquimico, para descartar posibles discrasias de las celulas plasmaticas y neoplasicas, de tal forma que el uso de estos auxiliares de diagnostico nos permitira sustentar de manera adecuada el tratamiento otorgado al paciente. Se presenta el caso de paciente femenino de 63 anos de edad, con una lesion tumoral/ulcerativa de la mucosa yugal izquierda de un mes de evolucion y lesion tumoral/ulcerativa de la mucosa yugal derecha de 15 dias de evolucion posterior a la aparicion de la primera lesion, tratada por un periodo de un ano con inmunosupresores de forma exitosa ya que a la fecha la paciente presenta inactiva la enfermedad. El proposito de este manuscrito es mostrar una de las localizaciones mas extranas de esta entidad patologica en la cavidad oral, sus caracteristicas clinicas e histologicas, establecer de forma correcta el diagnostico diferencial con otras entidades patologicas malignas o benignas y asi emplear el tratamiento requerido para la forma en que se presente la misma. Palabras clave:
Highlights
Plasma cell granuloma (PCG) has received the following names: inflammatory myofibroblastic tumor, inflammatory pseudotumor, fibrocystic inflammatory proliferation, xantomatosis pseudotumor, benign miofibroblastoma and inflammatory fibrosarcoma; in this article the first term is used
The recent WHO7 classification of soft tissue tumors includes three basic variants of plasma cell granulomas: Miofibroblast pattern loosely arranged in a myxoid edematous background, showing plasma cells, lymphocytes, eosinophils and blood vessels
Its histopathological examination consists of a pure infiltrate of plasma cells arranged in relatively large sheets with a fine reticular stromal, while PCG shows a capillary network as its main feature
Summary
Plasma cell granuloma (PCG) has received the following names: inflammatory myofibroblastic tumor, inflammatory pseudotumor, fibrocystic inflammatory proliferation, xantomatosis pseudotumor, benign miofibroblastoma and inflammatory fibrosarcoma; in this article the first term is used. PCG is a rare non-neoplastic lesion first described in 1973 by Bahadori and Liebow, consisting of the proliferation of inflammatory cells with the predominance of plasma cells. It has been classified as an inflammatory pseudotumor that can affect any organ or soft tissue being common in lungs, vagina, and larynx[1,2,3]. Avecdo et al have reported the occurrence of this lesion on gingival tissue of the oral cavity. Kim et al reported about the presence of PCG on the gingival surface in patients receiving immunosuppressive drugs (cyclosporine A), showing hyperplasia in that area. The use of these drugs may be considered as an etiological factor[4]
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