A Rare Case of Plasma Cell Granuloma

Archana P Kanteti,W Patrick Kelsey,Ernesto Martinez Duarte,Sukumaran Anil

doi:10.1155/2020/8861918

Archana P Kanteti, W Patrick Kelsey + Show 2 more

Open Access

https://doi.org/10.1155/2020/8861918

Copy DOI

Abstract

Plasma cell granulomas (PCGs) or inflammatory pseudotumors are nonneoplastic lesions that consist of predominantly antibody-secreting plasma cells and innate immune cells such as neutrophils, macrophages, and eosinophils. Unlike in multiple myeloma, the plasma cells are polyclonal and present in a spindly fibroblast-rich stromal background. These lesions mainly occur in the lungs; however, they can arise in other organs. PCGs from the gingiva are extremely rare, and a proper diagnosis is crucial to treat these patients further. These tumors have an increased number of plasma cells that are immunoreactive with CD138 and are polyclonal for kappa and lambda light chains, confirming these proliferations' nonneoplastic nature. Surgical resection with clear margins, when possible, is the primary choice of treatment. Radiation and anti-inflammatory steroid therapy are other therapeutic approaches. Critical and careful examination by a pathologist is necessary to rule out plasma cell neoplasms. Here, we report a rare occurrence of gingival PCG in an elderly male.

Highlights

Plasma cell granulomas (PCGs) are benign inflammatory growths that commonly occur in the lungs and are rarely found in the oral cavity [1, 2]
Plasma cell granuloma occurring in the gingiva is rare [2]
We present and discuss the underlying pathology in the general context of PCGs

Summary

Introduction

Plasma cell granulomas (PCGs) are benign inflammatory growths that commonly occur in the lungs and are rarely found in the oral cavity [1, 2]. They typically consist of a mass collection of polyclonal plasma cells [2]. Plasma cell granuloma occurring in the gingiva is rare [2]. Mass-forming gross disease can mimic a malignant process. Accurate diagnosis is based on gross, radiographic, morphologic, and immunophenotypic characteristics [3]. We present and discuss the underlying pathology in the general context of PCGs

Case History

Findings

Discussion