Placental site trophoblastic disease in practice of gynecologist (case report).

Abstract

Gestational trophoblastic disease is uncommon in practice. Usually a hydatidiform mole, an invasive mole and a choriocarcinoma are known among gynecologists. The practitioners have much less information about diseases associated with the intermediate trophoblast. These rare forms of trophoblastic disease are almost impossible to diagnose clinically. The morphological differential diagnosis is also quite difficult. Just careful attention to details, methodical study of the material, starting with routine staining methods, ending with immunohistochemical analysis, the use of molecular and cytogenetic typing, make it possible to establish the correct diagnosis and choose an effective therapeutic strategy. The article describes a rare clinical case of a placental site trophoblastic disease which was manifested by an ordinary abnormal uterine bleeding and then successfully diagnosed only by pathology experts.