Abstract
Pipazethate HCL toxicity: A Mini Review
Highlights
PipazethateHCl is 2-(2-piperidinoethoxy)ethyl 10H-pyrido [3,2-b] [1,4]benzothiadiazine-10-carboxylate hydrochloride [1]
Somnolence, agitation, seizures and more frequently coma are the main neurological manifestations in those patients while respiratory symptoms ranges from Kussmaul breathing to respiratory depression and apnea
Neurological and respiratory manifestations are usually related to the central depressive effect of the drug and subsequently death is usually related to serious hypoxia [4]
Summary
Medical Research Institute, University of Alexandria, Egypt, Tel:. Pipazethate HCl is a centrally acting non-narcotic antitussive which is rarely used nowadays in developed countries while it is still widely used in developing countries. Drug toxicity is rarely reported in the literature and it includes wide variety of neurological, respiratory and cardiovascular symptoms. The aim of the work was to highlight the manifestations of the toxicity of this drug and to illustrate how to manage them for a better outcome and survival
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