Abstract
Background:Citrus limon(lemon) belongs to the Rutaceae family and has great therapeutic applications. The chemical ingredients ofC. limonhave been used in the formulation of several ethnic herbal medicines. The application of antibiotics has shown the development of drug resistance in antibacterial drugs. Due to the drug-resistant nature of microorganisms, there is an urgent need to develop a novel drug active against wildtype and MDR resistant strains of pathogens.Aim:The present study is an endeavor to characterize the juice ofC. limontowards its total antioxidants potential activity (FRAP), DPPH and antibacterial efficacy.Methods and Materials:The antimicrobial activity was evaluated using different bacterial species such asSalmonella typhi, Neisseria gonorrhoeae, Citrobacter species, Shigella flexneriandStaphylococcus epidermidis.Results:The results of the present study indicated the antibacterial potential ofC. limonfruit juice. Among the tested bacterial species,Shigella flexneridisplayed maximum inhibition followed by the other microbes such asStaphylococcus epidermidis, Citrobacter speciesandSalmonella typhi.Conclusion:These findings may be utilized in the development of cost effective, safe and efficient novel drugs active against several pathogenic multi drug-resistant microorganisms.
Highlights
Plants have been of great importance from ancient times for various reasons
The results of the present study indicated the antibacterial potential of C. limon fruit juice
Among the tested bacterial species, Shigella flexneri displayed maximum inhibition followed by the other microbes such as Staphylococcus epidermidis, Citrobacter species and Salmonella typhi
Summary
Plants are known to act as a vital source of natural products which may be utilized in the synthesis of new drugs to protect human beings from different pathogenic infections [1]. Neisseria gonorrhoeae (N. gonorrhoeae), known as gonococci, is a Gram-negative diplococcus bacterium. The species are facultatively intracellular and are found in pairs It is responsible for causing the sexually transmitted disease called gonorrhea. Gonococcal infection is a major health problem; nearly sixty million cases are reported worldwide annually. The site of infection of gonococcus (exclusive human pathogen) is urogenital epithelia. Antibiotic treatment is provided initially for the gonococcal infection [12, 13]. Due to the drug-resistant nature of microorganisms, there is an urgent need to develop a novel drug active against wildtype and MDR resistant strains of pathogens
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