Abstract
The leaves of Bauhinia monandra prepared as poultices are used in many Brazilian tribes and some Nigerian communities to relieve swelling and pains, arthritis, diabetes among other ailments. These folkloric claimed benefits inspired this study in which topical and systemic anti-inflammatory activities of a methanol extract of B. monandra leaves (MEBmL) was assessed in rodents. The anti-inflammatory activities of B. monandra were determined by egg albumin-induced (systemic) paw edema in rats, and xylene-induced (topical) ear edema in mice. Treatment of rats with MEBmL at different concentration (200 and 400 mg/kg) led to significant (p<0,05) reduction (31.0% and 28.0% respectively) of the egg albumin-induced paw edema. Topical application of mice ear with MEBmL (50, 100 mg/kg) also significantly (p<0.05) reduced (39.50% and 41.87% respectively) xylene-induced ear edema. Based on the findings of the study, B. monandra has a promising therapeutic potential with its anti-inflammatory activities as associated with folkloric use of the plant.
Highlights
Plant metabolites are important source of natural bioactive molecules with a vast range of pharmacological activities which are known to exert pharmacological actions in the body, thereby enhancing curative and preventive properties of different diseases [1]
In Brazil, leaves of the species B. purpurea Linn., B. forficata Link., and B. monandra Kurz. are commonly used as teas for treatment of diabetes [11].Due to the elevated costs of commercial diabetes medication, Brazilian folks often prefer the use of infusions of Bauhinia sp as alternative for treating diabetes, and other ailments [11,12,13].Report have shown a wide range of pharmacological activities from different species of this genus [11,12], but very few have reported the anti-inflammatory activity of B. monandra
Since there are scarce experimental studies about its anti-inflammatory activity, the scope of this study was to evaluate whether the methanolic extracts obtained from dried B. monandra leaves are able to promote anti-inflammation in animal models, and contributing phytoconstituents of this common medicinal plant in folk medicine
Summary
Plant metabolites are important source of natural bioactive molecules with a vast range of pharmacological activities which are known to exert pharmacological actions in the body, thereby enhancing curative and preventive properties of different diseases [1]. The non-steroidal anti-inflammatory drugs (NSAIDS) are usually used for the treatment of inflammatory conditions including osteoarthritis, rheumatoid arthritis, and musculoskeletal disorders [6]. They are generally used for symptomatic relief. Are commonly used as teas for treatment of diabetes [11].Due to the elevated costs of commercial diabetes medication, Brazilian folks often prefer the use of infusions of Bauhinia sp as alternative for treating diabetes, and other ailments [11,12,13].Report have shown a wide range of pharmacological activities from different species of this genus [11,12], but very few have reported the anti-inflammatory activity of B. monandra. Since there are scarce experimental studies about its anti-inflammatory activity, the scope of this study was to evaluate whether the methanolic extracts obtained from dried B. monandra leaves are able to promote anti-inflammation in animal models, and contributing phytoconstituents of this common medicinal plant in folk medicine
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