Anti-inflammatory activity of Yanshu spraying agent in animal models

Leiming Zhang,Hongsheng Wang,Fenghua Fu,Chengwen Lu,Jianqiao Zhang,Pengfei Yu,Tian Wang,Yating Chong,Yunli Xue

doi:10.3892/etm.2012.761

Leiming Zhang, Hongsheng Wang + Show 7 more

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https://doi.org/10.3892/etm.2012.761

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Abstract

Acute pharyngitis is characterized by an inflammation of the mucous membranes in the pharynx. Yanshu spraying agent was prepared according to the traditional Chinese formulation for the treatment of acute pharyngitis. The present study aimed to investigate the anti-inflammatory effect of Yanshu in xylene-induced ear edema in mice and carrageenan-induced paw edema in rats by measuring the degree of edema in the animal models. The histopathology and the levels of prostaglandin E2 (PGE2) and cycloxygenase-2 (COX-2) in the hind paws of the carrageenan-treated rats were also analyzed. The results showed that Yanshu significantly reduced ear edema in the mice and paw edema in the rats. Furthermore, treatment with Yanshu also reduced the number of inflammatory cells in tissue and decreased the production of PGE2 and COX-2. These results suggest that Yanshu possesses potent anti-inflammatory activity mediated by the inhibition of COX-2 expression which, in turn, downregulates the inflammatory mediator PGE2.

Highlights

Acute pharyngitis, an acute inflammation of the pharyngeal mucous membrane, is often caused by upper respiratory tract infection with a virus or bacteria
The aim of this study was to investigate the anti-inflammatory effects of Yanshu in the treatment of xylene- and carrageenan-induced acute inflammation in animals
The treatment of rats with Yanshu 400 but not Yanshu 200 significantly inhibited the development of paw edema at 2 h (P

Summary

Introduction

An acute inflammation of the pharyngeal mucous membrane, is often caused by upper respiratory tract infection with a virus or bacteria. Its clinical manifestations include soreness of the throat, cough, pain on swallowing and fever [1]. The most common causes of acute pharyngitis are viral infections [2]. Due to the predominantly viral cause, antibiotics have only a minor benefit upon the resolution of pharyngitis symptoms. In most cases the treatment of acute pharyngitis is symptomatic, focusing on the management of symptoms such as fever, pain and inflammation

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