Abstract
Sodium laurate was incorporated into polymer gels with a thermo-triggered function based on acryloyl-L-proline methyl ester, to give a further pH-triggered drug-delivery function. In the absence of sodium laurate, the gel remained unswelled in solutions ranging in pH from 3.0 to 9.0 at 37°C. However, a significant swelling occurred by introduction of sodium laurate at pH values greater than 5.0, followed by a reversal of the swelling after release of sodium laurate from within the gel. We conclude that the release of ketoprofen from sodium laurate-loaded poly(acryloyl-L-proline methyl ester) gels could be demonstrated in-vitro, suggesting that the loaded gels are promising as a pH- and thermo-specific drug carrier.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
