Abstract
Spectral, photophysical, photochemical and bovine serum albumin binding studies on some gallium(III) derivatives - {1,(4)-(tetrapyridyloxyphthalocyaninato)gallium(III), (α GaPc ); 2,(3)-(tetrapyridyloxyphthalocyaninato)gallium(III), (β GaPc ); and their quaternized derivatives: Q α GaPc and Q β GaPc )} are hereby presented. β-Substituted complexes are more fluorescent, but show lower tendencies to undergo intersystem crossing than the α-substituted, as judged by their fluorescence and triplet quantum yield values. The quaternized derivatives ( QGaPc ) are water-soluble and non-aggregated, which makes them potential photosensitizers of choice for photodynamic therapy applications; these amphiphilic compounds also bind strongly to bovine serum albumin in 1:1 stoichiometries, and with binding constants ( Kb) in the order of 106M−1.
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