Year-end Sale % OFF 
Abstract
Effective binding of cationic ball-type zinc phthalocyanine (BT-Pc) to G-quadruplex (G4) DNA molecules has already been demonstrated previously. This motivated us to investigate the PDT performance of BT-Pc in cell culture studies. Accordingly, the present work involves the application of BT-Pc to breast (MCF-7) and osteosarcoma (MG63) cancer cells, and also to healthy fibroblast cells (L929). Cell lines (CL) were irradiated at 640 nm wavelength, and the photodynamic activity was evaluated. The results show that cytotoxicity was significantly stronger in MCF-7 cells than in both L929 and MG63 cells (p < 0.05) in the absence of IPL irradiation. Also, we report that the application of l IPL provided significant photodynamic activity in MCF-7 and MG63 cells (p < 0.05). These results further suggest that BT-Pc might become a promising photosensitizer for future clinical trials.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
