Photodynamic therapy of penile leukoplakia: a case report

N A Shanazarov,T M Muratov,B G Kassymov,S V Zinchenko

doi:10.37895/2071-8004-2021-25-3-29-33

N A Shanazarov, T M Muratov + Show 2 more

Open Access

https://doi.org/10.37895/2071-8004-2021-25-3-29-33

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Abstract

Purpose: to describe a clinical case of successful application of photodynamic therapy (PDT) in a patient with leukoplakia of the glans penis skin.Material and methods. For PDT, chlorin-type photosensitizer “Photolon” was used. The photosensitizer (lyophilized powder) was diluted in 200.0 ml of 0.9 % sodium chloride solution, administered intravenously at dosage 1.5 mg/kg of body weight. After 2.5 hours, intravenous laser blood irradiation was performed with “Lakhta-Milon” laser device (output power – 100 mW, exposure – 30 minutes). Before PDT, ﬂuorescence diagnostics in ultraviolet light with wavelength 395–405 nm was performed. PDT technique was single-ﬁeld irradiation with output power 1800 mW (1.8 W), irradiation energy density – 150 J/cm2. Power density of laser light was 200 mW/cm2. Exposure time – 14 min.Results. After treatment, complete regression of the pathological focus and regeneration of healthy tissue were marked (one month).Conclusion. PDT in a patient with leukoplakia of glans penis is an effective and safe curative technique.

Highlights

Дна полости рта, языка, щек; аногенитальная область, головка полового члена и область препуциального мешка, окружность анального отверстия
Объективно на слизистой оболочке головки полового члена определялся патологический очаг белесоватого цвета, неправильной формы, бугристый, площадью до 2 см2, безболезненный при пальпации
9. Bilyalov A.I., Shanazarov N.A., Zinchenko S.V. Photodynamic therapy as alternative method of treatment of metastatic ovarian cancer with many recurrence: Case report

Summary

Introduction

Дна полости рта, языка, щек; аногенитальная область (вульва, клитор, влагалища, шейка матки), головка полового члена и область препуциального мешка, окружность анального отверстия. Abstract Purpose: to describe a clinical case of successful application of photodynamic therapy (PDT) in a patient with leukoplakia of the glans penis skin. PDT in a patient with leukoplakia of glans penis is an effective and safe curative technique. При начальных формах заболевания чаще всего используют терапевтический подход, предусматривающий устранение влияния этиологических факторов, вызывающих развитие факультативных и облигатных предраков кожи полового члена.

Results

Conclusion