Динамика показателей скорости распространения пульсовой волны и концентрации в крови высокочувствительного С-реактивного белка у пациентов с метаболическим синдромом под влиянием низкоинтенсивного лазерного излучения

Abstract

Purpose . The presented trial was aimed to study the influence of intravenous laser blood irradiation (ILBI) at the elasticity of vascular walls and at the concentration of C-reactive protein (hsCRP) in patients with metabolic syndrome (MS). Material and methods . 154 patients with MS (average age 36.5 ± 3.6 year) were examined and treated. All patients were divided into two groups: control group (32 patients) and studied group (122 patients). In the control group, MS was treated with the standard medicamentous approach: lipid-lowering therapy, hypoglycemic drugs, antihypertensive therapy. Patients from the studied group, in addition to medicamentous treatment, had a course of laser therapy by the ILBI technique (VLOK-405). Laser device “Matrix-VLOK” (Matrix Ltd, Russia) with wavelength 0.405 mkm, output power at the tip of main fiber 1–1.5 mW was used. Laser irradiation of blood lasted for 15 minutes in continuous mode; therapy course had 10 daily procedures with an interval for Saturday and Sunday. The hsCRP level was defined with Beckman Coulter AU480 analyzer (Beckman Coulter, USA) and Beckman Coulter diagnostic kits. To assess the elastic properties of blood vessels, the pulse wave propagation velocity (SRW) technique with Poly-Spectrum-12 sphygmographic attachment (Neurosoft Ltd, Ivanovo) was used. Results . ILBI has been found to have a positive effect at the elasticity of vascular walls which was manifested with reducing the pulse wave propagation velocity via vessels of muscle and elastic types till normal limits; ILBI also decreased hsCRP concentration till parameters which were seen in healthy subjects. Conclusion . ILBI can be used as a method of treating the metabolic syndrome, since laser therapy helps to significantly reduce the initially elevated levels of CRP in such patients which, most likely, is associated with subclinical inflammation in the vascular wall caused by the insulin resistance and hyperlipidemia. ILBI also reduces the pulse wave propagation velocity via vessels of both types, thereby improving elastic properties of the vascular wall.