Abstract
Photoactive metal complexes are emerging as promising clinical drug candidates for anticancer and antimicrobial treatments. Phototherapy, mainly as photodynamic therapy (PDT), photoactivated chemotherapy (PACT) and photothermal therapy (PTT), is attractive due to its high efficiency, precise localization, and novel mechanism of action. The introduction of photoactive metallodrugs has promoted the further development of phototherapy due to their rich biological and chemical diversity. Two photoactive metallodrugs have been approved for clinical use, while more are in clinical trials or development. In this Chapter, we aim to give a comprehensive description of photoactive metallodrugs, including their history, photophysics, photochemistry and mechanisms of action, as well as the design of novel photoactive metallodrugs, and drug delivery systems.
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